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Nature. 2010 Mar 25;464(7288):504-12. doi: 10.1038/nature08980.

The genetics of ageing.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA. cynthia.kenyon@ucsf.edu

Erratum in

  • Nature. 2010 Sep 30;467(7315):622.

Abstract

The nematode Caenorhabditis elegans ages and dies in a few weeks, but humans can live for 100 years or more. Assuming that the ancestor we share with nematodes aged rapidly, this means that over evolutionary time mutations have increased lifespan more than 2,000-fold. Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions.

PMID:
20336132
DOI:
10.1038/nature08980
[Indexed for MEDLINE]

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