Copper-catalyzed N-arylation of amides using (S)-N-methylpyrrolidine-2-carboxylate as the ligand

Chaoyu Wang; Lijuan Liu; Wei Wang; Dong-Sheng Ma; Hua Zhang

doi:10.3390/molecules15031154

Copper-catalyzed N-arylation of amides using (S)-N-methylpyrrolidine-2-carboxylate as the ligand

Molecules. 2010 Mar 2;15(3):1154-60. doi: 10.3390/molecules15031154.

Authors

Chaoyu Wang¹, Lijuan Liu, Wei Wang, Dong-Sheng Ma, Hua Zhang

Affiliation

¹ College of Chemical Engineering and Material, Heilongjiang University, Haerbin 150080, China. wgyxhz@126.com

Abstract

(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemistry*
Catalysis
Copper / chemistry*
Ligands
Magnetic Resonance Spectroscopy
Proline / analogs & derivatives*
Proline / chemistry
Spectrometry, Mass, Electrospray Ionization

Substances

Amides
Ligands
N-methylproline
Copper
Proline