Send to

Choose Destination
Trends Endocrinol Metab. 2010 Jul;21(7):435-40. doi: 10.1016/j.tem.2010.02.006. Epub 2010 Mar 23.

Hypoxia signaling and resistance in C. elegans.

Author information

Genetics, Development, and Cell Biology Department, Iowa State University, Ames, IA 50011, USA.


In normal development and homeostasis and in many disease states, cells and tissues must overcome the challenge of oxygen deprivation (hypoxia). The nematode C. elegans is emerging as an increasingly powerful system in which to understand how animals adapt to moderate hypoxia and survive extreme hypoxic insults. This review provides an overview of C. elegans responses to hypoxia, ranging from adaptation and arrest to death, and highlights some of the recent studies that have provided important insights into hypoxia signaling and resistance. Many of the key genes and pathways are evolutionarily conserved, and C. elegans hypoxia research promises to inform our understanding of oxygen-sensitive signaling and survival in mammalian development and disease.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center