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J Am Chem Soc. 2010 Apr 14;132(14):5024-6. doi: 10.1021/ja100503b.

Single-walled carbon nanotube-based chemiresistive affinity biosensors for small molecules: ultrasensitive glucose detection.

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1
Department of Chemical and Environmental Engineering, University of California, Riverside, California 92521, USA.

Abstract

We report for the first time single-walled carbon nanotube (SWNT)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weakly charged or uncharged molecules using a displacement format. The detection of glucose, a small, weakly charged molecule, by displacement of plant lectin (concavalin A) bound to a polysaccharide (dextran) immobilized on SWNTs with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.

PMID:
20334381
PMCID:
PMC3292278
DOI:
10.1021/ja100503b
[Indexed for MEDLINE]
Free PMC Article
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