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Appl Microbiol Biotechnol. 2010 May;86(5):1313-22. doi: 10.1007/s00253-010-2537-z. Epub 2010 Mar 24.

Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of L-lysine production strains.

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Institute of Microbiology and Biotechnology, University of Ulm, 89069, Ulm, Germany.


Carbohydrates exclusively serve as feedstock for industrial amino acid production with Corynebacterium glutamicum. Due to the industrial interest, knowledge about the pathways for carbohydrate metabolization in C. glutamicum steadily increases, enabling the rational design of optimized strains and production processes. In this review, we provide an overview of the metabolic pathways for utilization of hexoses (glucose, fructose), disaccharides (sucrose, maltose), pentoses (D-ribose, L-arabinose, D-xylose), gluconate, and beta-glucosides present in C. glutamicum. Recent approaches of metabolic engineering of L: -lysine production strains based on the known pathways are described and evaluated with respect to L: -lysine yields.

[Indexed for MEDLINE]

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