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Nat Rev Cancer. 2010 Apr;10(4):301-9. doi: 10.1038/nrc2819.

MYC as a regulator of ribosome biogenesis and protein synthesis.

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Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.


MYC regulates the transcription of thousands of genes required to coordinate a range of cellular processes, including those essential for proliferation, growth, differentiation, apoptosis and self-renewal. Recently, MYC has also been shown to serve as a direct regulator of ribosome biogenesis. MYC coordinates protein synthesis through the transcriptional control of RNA and protein components of ribosomes, and of gene products required for the processing of ribosomal RNA, the nuclear export of ribosomal subunits and the initiation of mRNA translation. We discuss how the modulation of ribosome biogenesis by MYC may be essential to its physiological functions as well as its pathological role in tumorigenesis.

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