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Cancer Prev Res (Phila). 2010 Apr;3(4):410-5. doi: 10.1158/1940-6207.CAPR-10-0040. Epub 2010 Mar 23.

Vaccine prevention of cancer: can endogenous antigens be targeted?

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1
Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3970 Reservoir Road Northwest, Washington, DC 20057, USA. weinerl@georgetown.edu

Abstract

This perspective on the report by Beatty et al. in this issue of the journal (beginning on page 438) discusses the prevention of cancer through vaccination strategies that target antigens associated with tumor promotion and progression. Such approaches were first developed for treating cancer. We address cancer vaccination in the context of a mouse model of inflammatory bowel disease expressing MUC1, an epithelial mucin aberrantly expressed during chronic inflammation and in colorectal carcinogenesis, and in a broader context that includes the potential of targeting the tumor microenvironment for immunoprevention in humans. Obstacles in developing effective cancer vaccines, including antigen selection, immunoediting, and tumor-mediated immunosuppression, are also discussed.

PMID:
20332297
PMCID:
PMC2853240
DOI:
10.1158/1940-6207.CAPR-10-0040
[Indexed for MEDLINE]
Free PMC Article
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