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Cancer Sci. 2010 May;101(5):1212-8. doi: 10.1111/j.1349-7006.2010.01501.x. Epub 2010 Jan 19.

Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cells.

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1
Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China.

Abstract

Colon cancer is a leading cause of morbidity and mortality in Western countries. Basic fibroblast growth factor (bFGF) was up-regulated in patients with colon cancer and was considered as a potential therapeutic target. In this study, we first demonstrated that a novel bFGF-binding peptide (named P7) inhibited proliferation of several colon cancer cell lines including HT-29, LoVo, and Caco2 cells stimulated by bFGF. Further investigations with HT-29 cells indicated that P7 arrested the cell cycle at the G0/G1 phase of bFGF-stimulated cells, reduced the levels of phospho-Erk1/Erk2 induced by bFGF, and caused significant changes in the expression of proteins related to proliferation, cell cycle, and cancer. Our results suggested that the bFGF-binding peptide has a potential antitumor effect on colon cancer.

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