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Eur Radiol. 2010 Sep;20(9):2213-20. doi: 10.1007/s00330-010-1769-8. Epub 2010 Mar 23.

Squamous cell carcinoma of the head and neck: diffusion-weighted MR imaging for prediction and monitoring of treatment response.

Author information

1
Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, Prince of Wales Hospital, Shatin, The Chinese University of Hong Kong, New Territories, Hong Kong, SAR, China. king2015@cuhk.edu.hk

Abstract

OBJECTIVE:

To investigate the role of diffusion-weighted imaging (DWI) in predicting and monitoring chemoradiotherapy response in head and neck squamous cell carcinoma (HNSCC).

METHODS:

Diffusion-weighted imaging was performed pre-treatment (n = 50), intra-treatment (n = 41) and post-treatment (n = 20). Apparent diffusion coefficient (ADC) values were correlated with locoregional failure (LF).

RESULTS:

Locoregional failure occurred in 20/50 (40%) patients. A significant correlation was found between LF and post-treatment ADC (p = 0.02) but not pre- or intra-treatment ADC. Serial change in ADC was even more significant (p = 0.00001), using a fall in ADC early (pre- to intra-treatment) or late (intra- to post-treatment) to indicate LF, achieved 100% specificity, 80% sensitivity and 90% accuracy.

CONCLUSIONS:

Single ADC measurements pre- or intra-treatment did not predict response, but ADC post-treatment was a marker for LF. Serial change in ADC was an even stronger marker, when using an early or late treatment fall in ADC to identify LF.

PMID:
20309553
DOI:
10.1007/s00330-010-1769-8
[Indexed for MEDLINE]
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