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Curr Opin Hematol. 2010 May;17(3):237-44. doi: 10.1097/MOH.0b013e3283386750.

Mechanisms of vascular stability and the relationship to human disease.

Author information

1
Molecular Medicine Program, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA.

Abstract

PURPOSE OF REVIEW:

The genetic basis for a variety of vascular malformation syndromes have been described, with an increasing functional understanding of the associated genes.

RECENT FINDINGS:

Genes responsible for familial vascular malformation syndromes have increasingly been shown to be involved in the control of vascular stability.

SUMMARY:

Genes involved in vascular stability pathways are good candidates for causing vascular malformation syndromes. Although these findings confirm the biologic importance of the involved pathways, further explanations are required to describe the focal nature of disease.

PMID:
20308891
PMCID:
PMC2859848
DOI:
10.1097/MOH.0b013e3283386750
[Indexed for MEDLINE]
Free PMC Article

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