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Dev Genes Evol. 2010 Jun;220(1-2):1-10. doi: 10.1007/s00427-010-0323-7. Epub 2010 Mar 20.

The Drosophila neural lineages: a model system to study brain development and circuitry.

Author information

1
Department of Molecular Cell and Developmental Biology, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Abstract

In Drosophila, neurons of the central nervous system are grouped into units called lineages. Each lineage contains cells derived from a single neuroblast. Due to its clonal nature, the Drosophila brain is a valuable model system to study neuron development and circuit formation. To better understand the mechanisms underlying brain development, genetic manipulation tools can be utilized within lineages to visualize, knock down, or over-express proteins. Here, we will introduce the formation and development of lineages, discuss how one can utilize this model system, offer a comprehensive list of known lineages and their respective markers, and then briefly review studies that have utilized Drosophila neural lineages with a look at how this model system can benefit future endeavors.

PMID:
20306203
PMCID:
PMC2886914
DOI:
10.1007/s00427-010-0323-7
[Indexed for MEDLINE]
Free PMC Article

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