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J Ethnopharmacol. 1991 Jan;31(1):75-83.

Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice.

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Amala Cancer Research Centre, Kerala, India.


In mice, an extract of Crocus sativus stigmas partially prevented the decreases in body weight, hemoglobin levels and leucocyte counts caused by 2 mg/kg of cisplatin i.p. for 5 days. Treatment with the C. sativus extract also significantly prolonged the life span of cisplatin-treated mice almost three-fold. In contrast, an extract of Nigella sativa seed only tended to protect from cisplatin-induced falls in hemoglobin levels and leucocyte counts.

[Indexed for MEDLINE]

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