Nosocomial transmission of respiratory syncytial virus in neonatal intensive care and intermediate care units: a prospective epidemiologic study

Pediatr Infect Dis J. 2010 Jul;29(7):669-70. doi: 10.1097/INF.0b013e3181d76d61.

Abstract

To test the hypothesis that a considerable number of preterm infants acquire respiratory syncytial virus (RSV) within the hospital during the postnatal stay, a prospective epidemiologic survey was performed. Nasopharyngeal swabs were taken twice weekly for a period of 8 weeks from preterm infants, medical/nursing staff, and parents during the peak of RSV season 2007/2008 and tested for RSV by polymerase chain reaction. Of 1002 samples, only 4 tested positive (2 from a patient, 2 from staff). Sequence analyses of the G protein demonstrated that nosocomial transmission did not occur between these individuals.

MeSH terms

  • Adult
  • Cluster Analysis
  • Cross Infection / epidemiology*
  • Cross Infection / transmission*
  • Cross Infection / virology
  • DNA, Viral / chemistry
  • DNA, Viral / genetics
  • DNA, Viral / isolation & purification
  • Female
  • Genotype
  • Health Personnel
  • Humans
  • Infant
  • Infant, Newborn
  • Intensive Care, Neonatal
  • Male
  • Nasopharynx / virology
  • Parents
  • Polymerase Chain Reaction
  • Prospective Studies
  • Respiratory Syncytial Virus Infections / epidemiology*
  • Respiratory Syncytial Virus Infections / transmission*
  • Respiratory Syncytial Virus Infections / virology
  • Respiratory Syncytial Virus, Human / isolation & purification*
  • Sequence Analysis, DNA
  • Viral Fusion Proteins / genetics

Substances

  • DNA, Viral
  • G glycoprotein, Respiratory syncytial virus
  • Viral Fusion Proteins