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Biochim Biophys Acta. 2010 Aug;1801(8):853-9. doi: 10.1016/j.bbalip.2010.03.004. Epub 2010 Mar 19.

Intracellular cholesterol homeostasis and amyloid precursor protein processing.

Author information

1
Georgetown University Medical Center, Department of Neuroscience, Washington, DC 20057, USA. mpb37@georgetown.edu

Abstract

Many preclinical and clinical studies have implied a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). In this review we will discuss the movement of intracellular cholesterol and how normal distribution, transport, and export of cholesterol are vital for regulation of the AD related protein, Abeta. We focus on cholesterol distribution in the plasma membrane, transport through the endosomal/lysosomal system, control of cholesterol intracellular signaling at the endoplasmic reticulum and Golgi, the HMG-CoA reductase pathway and finally export of cholesterol from the cell.

PMID:
20304094
PMCID:
PMC2886153
DOI:
10.1016/j.bbalip.2010.03.004
[Indexed for MEDLINE]
Free PMC Article

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