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Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. Epub 2010 Mar 19.

Serum ferritin: Past, present and future.

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1
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.

Abstract

BACKGROUND:

Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases.

SCOPE OF REVIEW:

In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool.

MAJOR CONCLUSIONS:

Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer.

GENERAL SIGNIFICANCE:

Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.

PMID:
20304033
PMCID:
PMC2893236
DOI:
10.1016/j.bbagen.2010.03.011
[Indexed for MEDLINE]
Free PMC Article
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