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J Pediatr. 2010 Apr;156(4):675-8. doi: 10.1016/j.jpeds.2009.12.019.

Booster vaccination after neonatal priming with acellular pertussis vaccine.

Author information

1
Department of Pediatrics, Johannes Gutenberg-University, Mainz, Germany. knuf@kinder.klinik.uni-mainz.de

Abstract

After a birth dose of acellular pertussis (aP) and diphtheria (DT)aP-hepatitis B virus (HBV)-inactivated polio vaccine (IPV)/Haemophilus influenza type b (Hib) at 2, 4, and 6 months, a booster dose of DTaP-HBV-IPV/Hib at 12 to 23 months induced strong anti-pertussis booster responses. Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00289796.

PMID:
20303444
DOI:
10.1016/j.jpeds.2009.12.019
[Indexed for MEDLINE]

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