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Curr Opin Chem Biol. 2010 Jun;14(3):347-61. doi: 10.1016/j.cbpa.2010.02.018. Epub 2010 Mar 18.

Privileged scaffolds for library design and drug discovery.

Author information

1
Columbia University, Department of Chemistry, Havemeyer Hall, MC 3129, 3000 Broadway, New York, NY 10027, USA.

Abstract

This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.

PMID:
20303320
PMCID:
PMC2908274
DOI:
10.1016/j.cbpa.2010.02.018
[Indexed for MEDLINE]
Free PMC Article

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