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Curr Opin Neurobiol. 2010 Apr;20(2):231-5. doi: 10.1016/j.conb.2010.02.005. Epub 2010 Mar 18.

Prefrontal control of fear: more than just extinction.

Author information

1
Department of Psychiatry, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. fsotresb@gmail.com

Abstract

Although fear research has largely focused on the amygdala, recent findings highlight cortical control of the amygdala in the service of fear regulation. In rodent models, it is becoming well established that the infralimbic (IL) prefrontal cortex plays a key role in extinction learning, and recent findings are uncovering molecular mechanisms involved in extinction-related plasticity. Furthermore, mounting evidence implicates the prelimbic (PL) prefrontal cortex in the production of fear responses. Both IL and PL integrate inputs from the amygdala, as well as other structures to gate the expression of fear via projections to inhibitory or excitatory circuits within the amygdala. We suggest that dual control of the amygdala by separate prefrontal modules increases the flexibility of an organism's response to danger cues.

PMID:
20303254
PMCID:
PMC2878722
DOI:
10.1016/j.conb.2010.02.005
[Indexed for MEDLINE]
Free PMC Article

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