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Trends Neurosci. 2010 Apr;33(4):173-82. doi: 10.1016/j.tins.2010.01.005. Epub 2010 Mar 19.

Spatially restricting gene expression by local translation at synapses.

Author information

1
Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles (UCLA), Los Angeles, USA.

Abstract

mRNA localization and regulated translation provide a means of spatially restricting gene expression within each of the thousands of subcellular compartments made by a neuron, thereby vastly increasing the computational capacity of the brain. Recent studies reveal that local translation is regulated by stimuli that trigger neurite outgrowth and/or collapse, axon guidance, synapse formation, pruning, activity-dependent synaptic plasticity, and injury-induced axonal regeneration. Impairments in the local regulation of translation result in aberrant signaling, physiology and morphology of neurons, and are linked to neurological disorders. This review highlights current advances in understanding how mRNA translation is repressed during transport and how local translation is activated by stimuli. We address the function of local translation in the context of fragile X mental retardation.

PMID:
20303187
PMCID:
PMC3503250
DOI:
10.1016/j.tins.2010.01.005
[Indexed for MEDLINE]
Free PMC Article

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