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Leuk Res. 2010 Dec;34(12):1566-72. doi: 10.1016/j.leukres.2010.02.021. Epub 2010 Mar 29.

A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome.

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1
Institute of Hematology and Blood Transfusion, Prague, Czech Republic.

Abstract

Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS.

PMID:
20303173
DOI:
10.1016/j.leukres.2010.02.021
[Indexed for MEDLINE]

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