Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biomed Biotechnol. 2010;2010:294389. doi: 10.1155/2010/294389. Epub 2010 Mar 15.

Cytokines and their STATs in cutaneous and visceral leishmaniasis.

Author information

  • 1Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA.

Abstract

Cytokines play a critical role in shaping the host immune response to Leishmania infection and directing the development of protective and non-protective immunities during infection. Cytokines exert their biological activities through the activation and translocation of transcription factors into the nucleus whether they drive the expression of specific cytokine-responsive genes. Signal transducer and activator of transcription (STATs) are transcription factors which play a critical role in mediating signaling downstream of cytokine receptors and are important for shaping the host immune response during Leishmania infection. Here we discuss the signature cytokines and their associated STATs involved in the host immune response during cutaneous and visceral leishmaniasis.

PMID:
20300429
PMCID:
PMC2840379
DOI:
10.1155/2010/294389
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center