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Nat Rev Genet. 2010 Apr;11(4):285-96. doi: 10.1038/nrg2752.

Chromatin structure and the inheritance of epigenetic information.

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1
Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, 522 First Avenue, New York, New York 10016, USA.

Abstract

Although it is widely accepted that the regulation of the chromatin landscape is pivotal to conveying the epigenetic program, it is still unclear how a defined chromatin domain is reproduced following DNA replication and transmitted from one cell generation to the next. Here, we review the multiple mechanisms that potentially affect the inheritance of epigenetic information in somatic cells. We consider models of how histones might be recycled following replication, and discuss the importance of positive-feedback loops, long-range gene interactions and the complex network of trans-acting factors in the transmission of chromatin states.

PMID:
20300089
PMCID:
PMC3760772
DOI:
10.1038/nrg2752
[Indexed for MEDLINE]
Free PMC Article
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