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Science. 2010 Mar 19;327(5972):1522-6. doi: 10.1126/science.1181759.

Circadian gating of the cell cycle revealed in single cyanobacterial cells.

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1
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Abstract

Although major progress has been made in uncovering the machinery that underlies individual biological clocks, much less is known about how multiple clocks coordinate their oscillations. We simultaneously tracked cell division events and circadian phases of individual cells of the cyanobacterium Synechococcus elongatus and fit the data to a model to determine when cell cycle progression slows as a function of circadian and cell cycle phases. We infer that cell cycle progression in cyanobacteria slows during a specific circadian interval but is uniform across cell cycle phases. Our model is applicable to the quantification of the coupling between biological oscillators in other organisms.

PMID:
20299597
PMCID:
PMC3118046
DOI:
10.1126/science.1181759
[Indexed for MEDLINE]
Free PMC Article
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