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Curr Opin Cell Biol. 2010 Jun;22(3):284-90. doi: 10.1016/j.ceb.2010.02.002. Epub 2010 Mar 17.

Chromatin as a potential carrier of heritable information.

Author information

1
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA. Paul.Kaufman1@umassmed.edu

Abstract

Organisms with the same genome can inherit information in addition to that encoded in the DNA sequence-this is known as epigenetic inheritance. Epigenetic inheritance is responsible for many of the phenotypic differences between different cell types in multicellular organisms. Work by many investigators over the past decades has suggested that a great deal of epigenetic information might be carried in the pattern of post-translational modifications of the histone proteins, although this is not as well established as many believe. For example, it is unclear whether and how the histones, which are displaced from the chromosome during passage of the replication fork and are often exchanged from the DNA template at other times, carry information from one cellular generation to the next. Here, we briefly review the evidence that some chromatin states are indeed heritable, and then focus on the mechanistic challenges that remain in order to understand how this inheritance can be achieved.

PMID:
20299197
PMCID:
PMC3022377
DOI:
10.1016/j.ceb.2010.02.002
[Indexed for MEDLINE]
Free PMC Article

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