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Epilepsy Res. 2010 Jun;90(1-2):167-70. doi: 10.1016/j.eplepsyres.2010.02.011. Epub 2010 Mar 17.

Clomipramine increases the incidence and duration of spike-wave discharges in freely moving WAG/Rij rats.

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1
Department of Zoology, University of West Hungary Savaria Campus, Szombathely, Károlyi Gáspár tér 4, 9700 Hungary. zskovacs@ttmk.nyme.hu

Abstract

PURPOSE:

The noradrenergic and serotonergic system may have a role in modulation of absence seizures. We investigated whether the single injection of monoamine reuptake inhibitor clomipramine has an acute effect on spike-wave discharge (SWD) activity in Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats.

METHODS:

We injected a single dose of 20 or 50 mg/kg clomipramine intraperitoneally into WAG/Rij rats and measured the incidence and duration of SWD episodes for 4h after injection. The changes in SWDs were compared to the preceding 5-day average control level.

RESULTS:

The 20 mg/kg clomipramine significantly increased the incidence of SWDs in the first measured hour while the 50 mg/kg dose significantly increased the incidence and duration of SWDs in the whole measured 4-h period.

CONCLUSIONS:

Clomipramine, by acutely elevating synaptic monoamine levels, could exacerbate absence seizures.

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