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Biol Psychiatry. 2010 Aug 1;68(3):219-22. doi: 10.1016/j.biopsych.2010.01.028. Epub 2010 Mar 17.

Classification of alcohol abuse by plasma protein biomarkers.

Author information

1
Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania, USA.

Abstract

BACKGROUND:

Biochemical diagnostics of ethanol intake would improve alcohol abuse treatment and have applications in clinical trial and public safety settings. Self-reporting of alcohol use has clinical utility but lacks the desired reliability. Previously, proposed single-analyte biochemical tests of alcohol intake suffer from low sensitivity and specificity or examine only acute drinking and have therefore seen limited clinical use.

METHODS:

To address this unmet need, plasma protein biomarker discovery and validation were performed with an alcohol self-administering nonhuman primate model system to develop a diagnostic that accurately classifies subjects into nondrinking, nonabusive drinking, and abusive drinking categories.

RESULTS:

A 17-plasma protein panel was determined that correctly classifies abusive drinking with 100% sensitivity and also differentiates any level of drinking from alcohol abstinence with 88% accuracy.

CONCLUSIONS:

The biomarker panel reflects changes in multiple organ systems and suggests robust changes in the plasma proteome with drinking that might serve as a sensitive and specific diagnostic test. The specific plasma proteins altered with alcohol self-administration might represent indicators of alcohol-induced stress on a variety of organ systems.

PMID:
20299005
PMCID:
PMC2890298
DOI:
10.1016/j.biopsych.2010.01.028
[Indexed for MEDLINE]
Free PMC Article
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