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Exp Cell Res. 2010 May 15;316(9):1513-22. doi: 10.1016/j.yexcr.2010.03.002. Epub 2010 Mar 16.

Identification of a lysine-rich region of Fas as a raft nanodomain targeting signal necessary for Fas-mediated cell death.

Author information

1
Université de Nice Sophia-Antipolis, CNRS UMR 6543, Institute of Developmental Biology and Cancer Research, Equipe labelisée La Ligue, Nice, France.

Abstract

Fas interaction at the plasma membrane with its lipid and protein environment plays a crucial role in the early steps of Fas signalling induced by Fas ligand binding. Particularly, Fas localisation in the raft nanodomains, ezrin-mediated interaction with the actin cytoskeleton and subsequent internalization are critical steps in Fas-mediated cell death. We identified a lysine-rich region (LRR) in the cytoplasmic, membrane-proximal region of Fas as a key determinant modulating these initial events. Through a genetic approach, we demonstrate that Fas LRR represents another signal additional to palmitoylation targeting Fas to the raft nanodomains, and modulates Fas interaction with the cytoskeleton.

PMID:
20298688
DOI:
10.1016/j.yexcr.2010.03.002
[Indexed for MEDLINE]

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