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Biochem Soc Trans. 2010 Apr;38(2):422-7. doi: 10.1042/BST0380422.

Ancient machinery embedded in the contemporary ribosome.

Author information

1
Department of Structural Biology, Weizmann Institute, 2 Herzl Street, Rehovot, 76100 Israel.

Abstract

Structural analysis, supported by biochemical, mutagenesis and computational evidence, indicates that the peptidyltransferase centre of the contemporary ribosome is a universal symmetrical pocket composed solely of rRNA. This pocket seems to be a relic of the proto-ribosome, an ancient ribozyme, which was a dimeric RNA assembly formed from self-folded RNA chains of identical, similar or different sequences. This could have occurred spontaneously by gene duplication or gene fusion. This pocket-like entity was capable of autonomously catalysing various reactions, including peptide bond formation and non-coded or semi-coded amino acid polymerization. Efforts toward the structural definition of the early entity capable of genetic decoding involve the crystallization of the small ribosomal subunit of a bacterial organism harbouring a single functional rRNA operon.

PMID:
20298195
DOI:
10.1042/BST0380422
[Indexed for MEDLINE]

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