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Biochem Soc Trans. 2010 Apr;38(2):417-21. doi: 10.1042/BST0380417.

Catalysis of site-specific recombination by Tn3 resolvase.

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1
Faculty of Biomedical and Life Sciences, University of Glasgow, Bower Building, Glasgow G12 8QQ, UK. F.Olorunniji@bio.gla.ac.uk

Abstract

The active-site interactions involved in the catalysis of DNA site-specific recombination by the serine recombinases are still incompletely understood. Recent crystal structures of synaptic gammadelta resolvase-DNA intermediates and biochemical analysis of Tn3 resolvase mutants have provided new insights into the structure of the resolvase active site, and how interactions of the catalytic residues with the DNA substrate might promote the phosphoryl transfer reactions.

PMID:
20298194
DOI:
10.1042/BST0380417
[Indexed for MEDLINE]
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