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Nucleic Acids Res. 1991 Apr 11;19(7):1469-74.

Non-methylated islands in fish genomes are GC-poor.

Author information

1
Research Institute for Molecular Pathology, Vienna, Austria.

Abstract

In the vertebrate genomes studied to date the 5' end of many genes are associated with distinctive sequences known as CpG islands. CpG islands have three properties: they are non-methylated; the dinucleotide CpG occurs at the frequency predicted by base composition; and they are GC-rich. Unexpectedly we have found that CpG islands in certain fish only have the first two properties; that is, their GC-content is not elevated compared to bulk genomic DNA. Based on this finding, we speculate that the GC-richness of CpG islands in vertebrates other than fish is a passive consequence of a higher mutation rate in regions of open chromatin under conditions where the nucleotide precursor pools are biased.

PMID:
2027755
PMCID:
PMC333903
DOI:
10.1093/nar/19.7.1469
[Indexed for MEDLINE]
Free PMC Article

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