Format

Send to

Choose Destination
Nucleic Acids Res. 1991 Apr 11;19(7):1431-6.

The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers.

Author information

1
Institut de Pharmacologie du CNRS, Valbonne, France.

Abstract

We have isolated a human cDNA (kup), encoding a new protein with two distantly spaced zinc fingers of the C2H2 type. This gene is highly conserved in mammals and is expressed mainly in hematopoietic cells and testis. Its expression was not higher in the various transformed cells tested than in the normal corresponding tissues. The kup gene is located in region q23-q24 of the long arm of human chromosome 14. The kup protein is 433 a.a. long, has a M.W. close to 50 kD and binds to DNA. Although the structure of the kup protein is unusual, the isolated fingers resemble closely those of the Kr├╝ppel family, suggesting that this protein is also a transcription factor. The precise function and DNA motif recognized by the kup protein remain to be determined.

PMID:
2027750
PMCID:
PMC333897
DOI:
10.1093/nar/19.7.1431
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Silverchair Information Systems Icon for PubMed Central
Loading ...
Support Center