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Nature. 1991 May 2;351(6321):72-4.

Specific binding of antigenic peptides to cell-associated MHC class I molecules.

Author information

1
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

Abstract

T lymphocytes recognize antigen in the form of peptides that associate with specific alleles of class I or class II major histocompatibility (MHC) molecules. By contrast with the clear MHC allele-specific binding of peptides to purified class II molecules purified solubilized class I molecules either bind relatively poorly or show degenerate specificity. Using photo-affinity labelling, we demonstrate here the specific interaction of peptides with cell-associated MHC class I molecules and show that this involves metabolically active processes.

PMID:
2027386
DOI:
10.1038/351072a0
[Indexed for MEDLINE]

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