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J R Soc Med. 1991 Apr;84(4):221-3.

Epilepsy after craniotomy and the place of prophylactic anticonvulsant drugs: discussion paper.

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  • 1Mersey Regional Department of Medical & Surgical Neurology, Walton Hospital, Liverpool.

Abstract

A retrospective study of 1000 patients who had undergone supratentorial neurosurgery and with prolonged follow-up revealed an overall postoperative incidence of epilepsy of 17%. The incidence varied with different pathologies but anticonvulsants given prophylactically in a randomized trial did not significantly alter the incidence. Routine anticonvulsant prophylaxis cannot be recommended.

PMID:
2027149
PMCID:
PMC1293187
[PubMed - indexed for MEDLINE]
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