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J Antibiot (Tokyo). 1991 Mar;44(3):357-65.

Novel avermectins produced by mutational biosynthesis.

Author information

1
Central Research Division, Pfizer Ltd., Kent, England.

Abstract

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.

PMID:
2026561
[Indexed for MEDLINE]
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