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Biochem Biophys Res Commun. 1991 Mar 29;175(3):866-71.

Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene.

Author information

1
Department of Biochemistry, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.

Abstract

To clarify the mechanism of transcriptional induction of the rat liver acyl-CoA oxidase gene by hypolipidemic agents, we searched for cis-acting regulatory sequences in the 5' upstream region of the gene by transfection studies. We found that the sequence between -639 and -472 acts as a peroxisome proliferator-responsive, tissue-specific enhancer. Footprint analysis revealed two protein binding sites in this region. One of these sequences exhibited a positive, whereas the other a negative, regulatory activity in transcription assays.

PMID:
2025260
DOI:
10.1016/0006-291x(91)91645-s
[Indexed for MEDLINE]

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