Format

Send to

Choose Destination
Genome Inform. 2010 Jan;22:202-13.

CaMPDB: a resource for calpain and modulatory proteolysis.

Author information

1
Bioinformatics Center, Kyoto University, Gokasho, Uji 611-0011, Japan. dave@kuicr.kyoto-u.ac.jp

Abstract

While the importance of modulatory proteolysis in research has steadily increased, knowledge on this process has remained largely disorganized, with the nature and role of entities composing modulatory proteolysis still uncertain. We built CaMPDB, a resource on modulatory proteolysis, with a focus on calpain, a well-studied intracellular protease which regulates substrate functions by proteolytic processing. CaMPDB contains sequences of calpains, substrates and inhibitors as well as substrate cleavage sites, collected from the literature. Some cleavage efficiencies were evaluated by biochemical experiments and a cleavage site prediction tool is provided to assist biologists in understanding calpain-mediated cellular processes. CaMPDB is freely accessible at http://calpain.org.

PMID:
20238430
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for World Scientific Publishing Company
Loading ...
Support Center