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Head Neck Pathol. 2010 Mar;4(1):44-8. doi: 10.1007/s12105-009-0154-x. Epub 2009 Dec 10.

Collagenous myofibroblastic tumor of the mandible: case report of a unique locally aggressive neoplasm.

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1
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Unit 85, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Abstract

We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.

PMID:
20237988
PMCID:
PMC2825531
DOI:
10.1007/s12105-009-0154-x
[Indexed for MEDLINE]
Free PMC Article
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