Format

Send to

Choose Destination
Mucosal Immunol. 2010 May;3(3):260-9. doi: 10.1038/mi.2010.10. Epub 2010 Mar 17.

Human primary gastric dendritic cells induce a Th1 response to H. pylori.

Author information

1
Department of Medicine (Gastroenterology), University of Alabama at Birmingham, Birmingham, Alabama, USA.

Abstract

Adaptive CD4 T-cell responses are important in the pathogenesis of chronic Helicobacter pylori gastritis. However, the gastric antigen-presenting cells that induce these responses have not yet been identified. Here we show that dendritic cells (DCs) are present in the gastric mucosa of healthy subjects and are more prevalent and more activated in the gastric mucosa of H. pylori-infected subjects. H. pylori induced gastric DCs isolated from noninfected subjects to express increased levels of CD11c, CD86 and CD83, and to secrete proinflammatory cytokines, particularly interleukin (IL)-6 and IL-8. Importantly, gastric DCs pulsed with live H. pylori, but not control DCs, mediated T-cell secretion of interferon-gamma. The ability of H. pylori to induce gastric DC maturation and stimulate gastric DC activation of Th1 cells implicates gastric DCs as initiators of the immune response to H. pylori.

PMID:
20237463
PMCID:
PMC3683837
DOI:
10.1038/mi.2010.10
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center