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J Clin Microbiol. 2010 May;48(5):1939-42. doi: 10.1128/JCM.02261-09. Epub 2010 Mar 17.

Novel Burkholderiales 23S rRNA genes identified in ileal biopsy samples from children: preliminary evidence that a subtype is associated with perianal Crohn's disease.

Author information

  • 1Enteric Virus Group, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia. winnie.sim@mcri.edu.au

Abstract

A novel family of Burkholderiales bacteria was identified in ileal biopsy specimens from children presenting with symptoms of inflammatory bowel disease. A molecular subtyping approach based on sequencing of a variable region of the bacteria's 23S rRNA genes identified three variants. Pilot analysis identified one variant to be significantly associated with perianal Crohn's disease.

PMID:
20237101
PMCID:
PMC2863914
DOI:
10.1128/JCM.02261-09
[PubMed - indexed for MEDLINE]
Free PMC Article
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