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Trends Biochem Sci. 2010 Jul;35(7):384-91. doi: 10.1016/j.tibs.2010.02.005. Epub 2010 Mar 16.

HSP90 manages the ends.

Author information

1
Department of Cell and Developmental Biology, University of Illinois, Urbana-Champaign, Urbana, IL 61801, USA.

Abstract

The telomere environment requires an efficient means to assemble and disassemble a multitude of structures to operate correctly and to help achieve cellular homeostasis. Telomeres are challenged by a common binding specificity displayed by many of the protein components for telomeric DNA, which could result in competitive DNA interactions, and by a cell cycle-restricted timing of events, which enforces a narrow working period in which to perform numerous tasks. In this review, we discuss how the HSP90 molecular chaperone network avoids these obstacles and facilitates an effective operation of the telomere system.

PMID:
20236825
PMCID:
PMC2891936
DOI:
10.1016/j.tibs.2010.02.005
[Indexed for MEDLINE]
Free PMC Article

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