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Eur J Neurol. 2010 Jul;17(7):969-75. doi: 10.1111/j.1468-1331.2010.02975.x. Epub 2010 Mar 3.

Caudate atrophy on MRI is a characteristic feature of FTLD-FUS.

Author information

1
Department of Neurology (Behavioral Neurology), Mayo Clinic, Rochester, MN 55905, USA. josephs.keith@mayo.edu

Abstract

BACKGROUND AND PURPOSE:

Frontotemporal lobar degeneration (FTLD) can be subdivided into those in which the abnormal protein is tau (FTLD-TAU), the TAR DNA binding protein 43 (FTLD-TDP) and the fused in sarcoma protein (FTLD-FUS). We have observed severe caudate atrophy at autopsy in FTLD-FUS, and hence, we aimed to determine whether caudate atrophy on MRI is a feature that can distinguish FTLD-FUS from FTLD-TDP and FTLD-TAU.

METHODS:

From a cohort of 207 cases of FTLD, we identified all cases of FTLD-FUS that had a volumetric antemortem head MRI (n = 3). Caudate and frontal lobe volumes were measured in all three cases using atlas-based parcellation and SPM5 and were compared to 10 randomly selected cases of FTLD-TDP and 10 randomly selected cases of FTLD-TAU. Total grey matter volumes were also calculated for all cases.

RESULTS:

The FTLD-FUS cases had significantly smaller caudate volumes (P = 0.02) yet similar frontal lobe grey matter volumes (P = 0.12) compared to FTLD-TDP and FTLD-TAU. Caudate volumes when corrected for total grey matter volume (P = 0.01) or frontal lobe grey matter volume (P = 0.01) were significantly smaller in FTLD-FUS than in FTLD-TDP and FTLD-TAU and showed no overlap with the other two groups.

CONCLUSIONS:

Caudate atrophy on MRI appears to be significantly greater in FTLD-FUS compared with FTLD-TDP and FTLD-TAU, suggesting that severe caudate atrophy may be a useful clinical feature to predict FTLD-FUS pathology.

PMID:
20236174
PMCID:
PMC2989679
DOI:
10.1111/j.1468-1331.2010.02975.x
[Indexed for MEDLINE]
Free PMC Article

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