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Curr Mol Med. 2010 Apr;10(3):292-5.

The role of PEDF in tumor growth and metastasis.

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Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.


Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.

[Indexed for MEDLINE]

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