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J Infect Dis. 2010 May 1;201(9):1298-302. doi: 10.1086/651664.

The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.

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1
Aaron Diamond AIDS Research Center, an affiliate of Rockefeller University, New York, New York, USA. mmarkowitz@adarc.org

Abstract

Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.

PMID:
20235838
PMCID:
PMC2851487
DOI:
10.1086/651664
[Indexed for MEDLINE]
Free PMC Article

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