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Nat Prod Res. 2011 Sep;25(15):1412-7. doi: 10.1080/14786410802425746. Epub 2011 Jul 8.

Antioxidant and NF-κB inhibitory constituents isolated from Morchella esculenta.

Author information

1
Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, OH, USA.

Abstract

Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells. The methylene chloride extract, which showed the highest antioxidant activity, led to the isolation of four fungal sterols, 1-4, and trilinolein (5), in addition to methyl myristate (6), 1-linoleoylglycerol (7), and ceramide (8). The isolated compounds were identified through the analysis of various spectroscopic methods. In the hydroxyl radical assay, 5-dihydroergosterol exhibited significant antioxidant activity. All compounds isolated were also tested using an enzyme-based Elisa NF-κB assay. Fungal sterols and trilinolein showed significant inhibition of NF-κB activation in the NF-κB assay.

PMID:
20234969
DOI:
10.1080/14786410802425746
[Indexed for MEDLINE]

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