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Nat Rev Microbiol. 2010 Apr;8(4):296-307. doi: 10.1038/nrmicro2321.

Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors.

Author information

1
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106-7288, USA. cvh3@cwru.edu

Abstract

Mycobacterium tuberculosis survives in antigen-presenting cells (APCs) such as macrophages and dendritic cells. APCs present antigens in association with major histocompatibility complex (MHC) class II molecules to stimulate CD4(+) T cells, and this process is essential to contain M. tuberculosis infection. Immune evasion allows M. tuberculosis to establish persistent or latent infection in macrophages and results in Toll-like receptor 2 (TLR2)-dependent inhibition of MHC class II transactivator expression, MHC class II molecule expression and antigen presentation. This reduction of antigen presentation might reflect a general mechanism of negative-feedback regulation that prevents excessive T cell-mediated inflammation and that M. tuberculosis has subverted to create a niche for survival in infected macrophages and evasion of recognition by CD4(+) T cells.

PMID:
20234378
PMCID:
PMC3037727
DOI:
10.1038/nrmicro2321
[Indexed for MEDLINE]
Free PMC Article

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