Format

Send to

Choose Destination
Drug Metab Rev. 2010 Aug;42(3):482-538. doi: 10.3109/03602531003654915.

Regulation of hepatic ABCC transporters by xenobiotics and in disease states.

Author information

1
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, 06269, USA.

Abstract

The subfamily of ABCC transporters consists of 13 members in mammals, including the multidrug resistance-associated proteins (MRPs), sulfonylurea receptors (SURs), and the cystic fibrosis transmembrane conductance regulator (CFTR). These proteins play roles in chemical detoxification, disposition, and normal cell physiology. ABCC transporters are expressed differentially in the liver and are regulated at the transcription and translation level. Their expression and function are also controlled by post-translational modification and membrane-trafficking events. These processes are tightly regulated. Information about alterations in the expression of hepatobiliary ABCC transporters could provide important insights into the pathogenesis of diseases and disposition of xenobiotics. In this review, we describe the regulation of hepatic ABCC transporters in humans and rodents by a variety of xenobiotics, under disease states and in genetically modified animal models deficient in transcription factors, transporters, and cell-signaling molecules.

PMID:
20233023
PMCID:
PMC4458072
DOI:
10.3109/03602531003654915
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center