Format

Send to

Choose Destination
See comment in PubMed Commons below
Chem Biodivers. 2010 Mar;7(3):536-42. doi: 10.1002/cbdv.200900343.

Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.

Author information

1
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M. rnv@ifk.sdu.dk

Abstract

Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.

PMID:
20232325
DOI:
10.1002/cbdv.200900343
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center