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J Invest Dermatol. 2010 Apr;130(4):926-8. doi: 10.1038/jid.2009.370.

More or less: copy number alterations in mycosis fungoides.

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1
Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Abstract

Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of non-Hodgkin's lymphomas of skin-homing T cells. MF may vary from limited patchy skin disease to extensive cutaneous plaque and tumor involvement to extracutaneous compartments of blood, lymph nodes, and viscera. Advances in genomic technologies have enabled the increasing characterization of genetic alterations in this malignancy; using this technology, investigators hope to understand MF's variable behavior and pathogenesis. In this issue, Salgado et al. identify regions of genomic DNA alterations from 41 MF samples and report associations with prognosis.

PMID:
20231832
DOI:
10.1038/jid.2009.370
[Indexed for MEDLINE]
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