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Dev Cell. 2010 Mar 16;18(3):340-1. doi: 10.1016/j.devcel.2010.03.005.

Switch NFix developmental myogenesis.

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1
Dulbecco Telethon Institute , IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00161 Roma, Italy.

Abstract

During development, skeletal muscles adapt to stage-specific functional and metabolic challenges by switching the expression of specific subset of genes. The mechanism that governs these changes is still enigmatic. In a recent issue of Cell, Messina and coworkers shed light on this issue through the identification of a transcription factor--NFix--that coordinates the switch in gene expression at the transition from embryonic to fetal myoblasts.

PMID:
20230743
DOI:
10.1016/j.devcel.2010.03.005
[Indexed for MEDLINE]
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