Format

Send to

Choose Destination
J Thromb Haemost. 2010 Jun;8(6):1170-5. doi: 10.1111/j.1538-7836.2010.03833.x. Epub 2010 Mar 3.

Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease.

Author information

1
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.

Abstract

BACKGROUND:

Osteoprotegerin (OPG) is a secretory glycoprotein which belongs to the tumor necrosis factor receptor family. OPG immunoreactivity was demonstrated in normal blood vessels and in early atherosclerotic lesions. In a previous study, we showed that high serum OPG levels are associated with progression of coronary artery disease (CAD).

OBJECTIVES:

The present study was designed to assess the association between serum OPG level and long-term prognosis in patients with stable coronary artery disease.

METHODS:

We performed a prospective, observational cohort study in 225 subjects to examine whether serum OPG levels can predict cardiovascular mortality. The median OPG levels were 1.02 ng mL(-1) at baseline.

RESULTS:

During the follow-up (61 + or - 25 months), 27 deaths occurred including 13 cardiovascular deaths. When the subjects were divided into three groups according to serum OPG level, the group with high serum OPG showed a higher risk for cardiovascular mortality. A Multivariate Cox proportional hazards model indicated that the higher risk of cardiovascular death in the high OPG level group remained significant (hazards ratio of 7.44, 95%CI 0.92-60.30, highest vs. lowest OPG tertile). In contrast, serum OPG levels were not associated with non-cardiovascular mortality.

CONCLUSIONS:

Our data show that serum OPG levels are an independent predictor of cardiovascular mortality in patients with stable coronary artery disease.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center